Membrane Adsorbers

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Some suppliers, such as Sartorius, Pall and Millipore, now sell membranes that have been given surface properties like those of chromatography beads. These membrane adsorbers (Gottschalk

Figure 18.8 The Pall Centrasette system can be directly scaled from a 0.01m2 scale-down model to industrial production scale with membrane areas of 80m2 or more, and capable of processing around 25,000L. (Above) (a) Pilot scale ultrafiltration equipment used in the concentration and diafiltration of a live virus herpes vaccine. The Pall Centramate system shown houses 0.5m2 of membrane and is driven by a 4-head diaphragm Quattro pump, also supplied by Pall. Photo courtesy of Jim Mills, rerpoduced with permission of Xenova.

Figure 18.8 The Pall Centrasette system can be directly scaled from a 0.01m2 scale-down model to industrial production scale with membrane areas of 80m2 or more, and capable of processing around 25,000L. (Above) (a) Pilot scale ultrafiltration equipment used in the concentration and diafiltration of a live virus herpes vaccine. The Pall Centramate system shown houses 0.5m2 of membrane and is driven by a 4-head diaphragm Quattro pump, also supplied by Pall. Photo courtesy of Jim Mills, rerpoduced with permission of Xenova.

Ultrafiltration System Cassettes
Figure 18.8 (Continued) (b) Two duplex Pall Centrastak™ 300 ultrafiltration systems, for use with Pall Centrasette™ cassettes, designed for large-scale downstream processing of biopharmaceutical products. Photo courtesy Pall Corporation.

et al. 2004) offer the advantage of very high flow rates because the binding of product relies much less on diffusion than is the case with chromatography beads. In addition, the breakthrough curve at the point where the membrane saturates with product is very steep, which is useful from the point of view of efficient use of the medium - where a chromatography column may only be partially saturated before significant product begins to breakthrough, the membranes should be almost completely saturated before breakthrough is detected.

Scale-up of membrane adsorbers is becoming increasingly common in the manufacture of biological medicines. Membrane adsorbers have been shown to contribute significantly to viral clearance in processes for production of biological medicines from animal cells (Gottschalk et al. 2004).

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