Pancreatic Cancer

The No Nonsense Teds Fat Melting

The No Nonsense Teds Fat Melting

Get Instant Access

Dietary components that are implicated in pancreatic cancer exert their influence as factors for pancreatitis and diabetes mellitus. For example, excessive alcohol intake is associated with pancreatitis, which is a risk factor for pancreatic cancer [31]. Similarly, excessive intake of simple carbohydrates exacerbates hyperglycemia in susceptible individuals, and diabetes is a risk factor for pancreatic cancer [32, 33].

2.5. Liver Cancer

Other than alcohol-related cirrhosis, carcinogenesis in the liver appears to be influenced only minimally by dietary constituents [34]. Factors such as cirrhosis, HBV and aflatoxin contamination seem to exert more of an influence over carcinogenesis [35].

2.6. Colorectal Cancer

Multiple micronutrients including calcium [36-39], vitamin D [39], folate [40] and selenium [41] appear to have colorectal chemopre-ventive properties. Calcium decreases colon epithelial hyperprolifer-ation induced by bile and fatty acids [41], while vitamin D seems to modulate the effects of calcium. Folate is involved in the donation of methyl groups and the proper functioning of methyltetrahydro-folate reductase. Interestingly, it appears that folate supplementation in those individuals without cancer confers a protective effect; however, in those with neoplastic tissue, it may increase risk of cancer [39]. Selenium enhances the peroxidation-inhibiting enzyme glutathione peroxidase and promotes coloncyte apoptosis, which may afford protection against colon carcinogenesis [41].

It has been suggested that high dietary fat intake may increase colon cancer risk. The proposed mechanism involves dietary fat-enhanced secretion of primary bile acids, which are converted to more cytotoxic secondary and tertiary bile acids by colonic bacteria [42]. The correlation of dietary fat intake with cancer incidence is somewhat controversial [42]. Although initial studies indicated a link between high dietary fat intake and cancer, more recently several epidemiologic studies have indicated a weak or no association [3, 43].

Was this article helpful?

0 0
Diet And Exercise Expertise

Diet And Exercise Expertise

Get All The Support And Guidance You Need To Be A Success At Dieting And Exercise. This Book Is One Of The Most Valuable Resources In The World When It Comes To Better Physical Personal Development Through Better Living.

Get My Free Ebook

Post a comment