Conclusion

Substantial advances have been made in our understanding of celiac disease, including the development of non-invasive techniques that can aid in the diagnosis and management of this disorder. Areas for further investigation include the pathogenesis and immunogenetics of celiac disease, and its relationship to other autoimmune diseases. Observations of an increased incidence of celiac disease have been attributed to increased amounts and the timing of the introduction of gluten in the diet of infants, and these warrant further examination. There is also a need for optimizing screening and diagnostic strategies and improving management, including the possible development of wheat strains deficient in gliadin [86]. New therapies are being developed and tested, including methods to digest gluten to non-immunogenic substances [87, 88], an inhibitor of zonulin and immunomodulatory therapies.

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