18.1 Type I Hypersensitivities: Immediate IgE-Mediated

1. IgE attached to mast cells or basophils reacts with specific antigen, resulting in the release of powerful mediators of the allergic reaction. (Figure 18.1)

Localized Anaphylaxis

1. Localized anaphylactic (type I) reactions include hives (urticaria), hay fever (allergic rhinitis), and asthma. (Figure 18.2)

Generalized Anaphylaxis

1. Generalized or systemic anaphylaxis is a rare but serious reaction that can lead to shock and death.

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