Resistant Cell

Increased elimination

Drug enters cell but efflux pump ejects it

Drug-inactivating enzyme

Enzyme modifies nactivating it

Alteration in target molecule

Drug cannot bind target

Decreased uptake

Porin proteins prevent entry into the cell

Figure 21.14 Common Mechanisms of Antimicrobial Drug Resistance

Decreased uptake

Porin proteins prevent entry into the cell

Figure 21.14 Common Mechanisms of Antimicrobial Drug Resistance

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