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In the United States, immunization of dogs against rabies has practically eliminated them as a source of human disease. The rabies virus remains rampant among wildlife, however, a constant threat to non-immunized domestic animals and humans. Many questions remain about the pathogenesis of rabies, and no effective treatment exists for the disease.


Rabies is one of the most feared of all diseases because its terrifying symptoms almost invariably end with death. Like many other viral diseases, it begins with fever, head and muscle aches, sore throat, fatigue, and nausea. The characteristic symptom that strongly suggests rabies is a tingling or twitching sensation at the site of viral entry, usually an animal bite. These early symptoms generally begin 1 to 2 months after viral entry and progress rapidly to symptoms of encephalitis, agitation, confusion, hallucinations, seizures, and increased sensitivity to light, sound, and touch. The body temperature then rises steeply, and increased salivation combined with difficulty swallowing result in frothing at the mouth. Hydrophobia, painful spasm of the throat and respiratory muscles provoked by swallowing or even seeing liquids, occurs in half the cases. Coma develops, and about 50% of patients die within 4 days of the first appearance of symptoms, the rest soon after.

Inactivated virus (Salk) vaccine

Inactivated virus (Salk) vaccine

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  • maximilian
    What Is The Causative Agent Of Rabies?
    2 years ago

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