Little is known about the pathogenesis of adenoviral disease. Humans are the only source of infection. Once inside the cells of the host, the virus multiplies in the nuclei. In severe infections, extensive cell destruction and inflammation occur. Different types of adenoviruses vary in the tissues they affect. For example, ade-novirus types 4, 7, and 21 typically cause illness characterized by sore throat and enlarged lymph nodes, whereas type 8 is likely to cause extensive eye infection.

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