Paba

Nester-Anderson-Roberts: I I. Life and Death of I 6. Metabolism: Fueling Cell I I © The McGraw-Hill

Microbiology, A Human Microorganisms Growth Companies, 2003

Perspective, Fourth Edition

Figure 6.15 Glycolysis The glycolytic pathway oxidizes glucose to pyruvate, generating ATP by substrate-level phosphorylation, reducing power in the form of NADH, and 6 different precursor metabolites.

6.3 The Central Metabolic Pathways 143

ATP XKX)

Step 1: ATP is expended to add a phosphate group.

Glucose 6-phosphate

Fructose 6-phosphate

Step 2: A chemical rearrangement occurs.

Fructose 1,6-bisphosphate

Step 3: ATP is expended to add a phosphate group.

Dihydroxyacetone phosphate

Glyceraldehyde 3-phosphate Q

nadJ-

1,3-bisphospho- V

Step 5: A chemical rearrangement of one of the molecules occurs.

Step 6: The addition of a phosphate NAD^ group is coupled to an oxidation,

Step 4: The 6-carbon molecule is split into two 3-carbon molecules.

Step 5: A chemical rearrangement of one of the molecules occurs.

Step 6: The addition of a phosphate NAD^ group is coupled to an oxidation,

OOQh)

generating NADH and a high-energy phosphate bond.

KI^ Step 7: ATP is produced by substrate-level ""1CH-hJ phosphorylation.

3-phospho-glycerate

2-phospho-glycerate

CKK^

Phospho-enolpyruvate

Step 8: A chemical rearrangement occurs.

Step 9: Water is removed, causing H o) the phosphate bond to become high-energy.

Pyruvate]

Step 10: ATP is produced by substrate-level phosphorylation.

Glucose

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