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Integrated DNA (provirus)

Integration of DNA copy into host chromosome

Host DNA

Many RNA copies each coding for many proteins

Polyprotein

Host DNA

Transcription of viral genes

Transcription of viral genes

Translation of viral RNA into polyprotein

Protease cleaves polyprotein into individual proteins

Capsid protein Envelope protein (spikes) Reverse transcriptase

Capsid protein Envelope protein (spikes) Reverse transcriptase

Assembly of many new virus particles each containing reverse transcriptase.

14.4 Virus-Induced Tumors—General Aspects 357

Figure 14.14 Replication Cycle of a Retrovirus A retrovirus is the cause of AIDS and many tumors in animals.

reverse transcriptase, which copies the single-stranded RNA of the virion into DNA which then becomes integrated into certain cells of the immune system.

■ Name the two major kinds of infections that viruses cause.

■ What is a major difference in the entry of animal viruses and bacterial viruses into their host cells?

■ How do animal viruses cause lysis of the host cell?

■ Explain why HIV becomes resistant to drugs so quickly.

Assembly of many new virus particles each containing reverse transcriptase.

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