Figure 29.11 Mode of Action of Zidovudine (AZT) (a) Normal elongation process of DNA in which reverse transcriptase catalyzes the reaction between the OH group on the chain with the phosphate group of the nucleotide being added. (b) Reverse transcriptase catalyzes the reaction of zidovudine with the growing DNA chain. Since zidovudine lacks the reactive OH group, no further additions to the chain can occur, and DNA synthesis is halted.T = thymine, C = cytosine, A = adenine.

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