Nad

(c) Adenyl cyclase causes the conversion of ATP to cAMP.

(e) Reaction summary:

Locked G protein

Figure 24.13 Mode of Action of Cholera Toxin As with other A-B toxins, the B portion attaches the toxin to the host cell, and the A portion penetrates the cell and causes toxicity. In this case, the target of the A portion is a G protein responsible for regulating production of cAMP. By splitting off the ADP-ribose portion of NAD and attaching it to G, the toxin makes it impossible for G to down-regulate cAMP production.

Was this article helpful?

0 0
Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook


Post a comment