Nad

(c) Adenyl cyclase causes the conversion of ATP to cAMP.

(e) Reaction summary:

Locked G protein

Figure 24.13 Mode of Action of Cholera Toxin As with other A-B toxins, the B portion attaches the toxin to the host cell, and the A portion penetrates the cell and causes toxicity. In this case, the target of the A portion is a G protein responsible for regulating production of cAMP. By splitting off the ADP-ribose portion of NAD and attaching it to G, the toxin makes it impossible for G to down-regulate cAMP production.

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