Mutations, changes in the nucleotide sequence of DNA, may result in proteins that are non-functional, thereby altering the properties of the cell. A leaky mutation results in a partially functional protein; a knockout mutation results in a non-functional protein. Mutations most commonly occur spontaneously as a result of mistakes in DNA replication.

■ How would the growth requirements change in a cell that has a silent mutation in a gene for histidine synthesis? How would it change if the mutation were a knockout?

■ Would the addition of three bases to DNA always lead to a frameshift mutation? Explain your answer.

Bacterial Vaginosis Facts

Bacterial Vaginosis Facts

This fact sheet is designed to provide you with information on Bacterial Vaginosis. Bacterial vaginosis is an abnormal vaginal condition that is characterized by vaginal discharge and results from an overgrowth of atypical bacteria in the vagina.

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