The first genomic sequence of a microorganism was completed in 1995. The sequencing methodologies are quickly becoming more rapid, but analyzing the data and extracting the pertinent information is difficult.

■ What is an open reading frame?

■ Describe two things that can be learned by searching a computerized database for sequences that have homologies to a newly sequenced gene.

■ There are some characteristic differences in the nucleotide sequences of the leading and lagging strands. Why might this be so?

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