Microcheck 292

Certain DNA viruses are strongly associated with development of malignant tumors in patients with HIV disease. These viruses are not sufficient by themselves to cause malignancy, but require the presence of other conditions. The tumors all arise in a setting of increased cell proliferation caused in part by the viruses. Many of these tumors are preventable by safer sex practices and screening for premalignant lesions.

■ What HIV gene product appears to play a role in development of Kaposi's sarcoma?

■ What member of the herpesvirus family is associated with almost all of the B-cell lymphomas of the brain in AIDS patients?

■ What measure is important to prevent cervical and anal carcinomas in persons with HIV disease?

■ Would rapidly dividing cells favor mutation?

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