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The Revised Authoritative Guide To Vaccine Legal Exemptions

Vaccines Have Serious Side Effects

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Herpes simplex is characterized by acute infection followed by lifelong latency and the possibility of recurrent disease. Infectious virus is often present in saliva in the absence of symptoms. Mumps virus infections characteristically cause enlargement of the parotid glands, but they can involve the brain, testicles, and ovaries, and cause miscarriages. Mumps is a good candidate for eradication.

■ What infections are caused by the two types of herpes simplex viruses?

■ Why would you expect acyclovir to be ineffective against latent herpes simplex viral infections?

■ Why is mumps a good candidate for eradication from the world?

Figure 24.11 Reported Cases of Mumps, United States, 1973-2001

Mumps vaccine was licensed in 1967.There were only 231 cases reported for the year 2001.

Table 24.4 Mumps

Symptoms

Fever, headache, loss of appetite, typically followed by painful swelling of one or both parotid glands. Painful enlargement of the testicles, pelvic pain in women, and symptoms arising from brain involvement are likely to occur in individuals past the age of puberty

Incubation period

Generally 15 to 21 days

Causative agent

Mumps virus, a single-stranded RNA virus of the paramyxovirus family

Pathogenesis

The virus initially replicates in the upper respiratory tract, then disseminates to the parotids and other organs of the body via the bloodstream. The inflammatory response to cell destruction is responsible for the marked swelling and pain

Epidemiology

Humans are the only source of the virus. Transmission is favored by a high percentage of asymptomatic infections

Prevention and treatment

An effective attenuated vaccine has been used since 1967. No antiviral therapy is available

Chapter 24 Alimentary System Infections

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