Because fungi are eukaryotic cells, there are relatively few targets for selectively toxic antifungal drugs. Most antifungal drugs interfere with the function or synthesis of ergosterol, which is found in the membrane of fungal but not human cells. Some antifungal drugs target cell division and nucleic acid synthesis.
■ Why is amphotericin B, a polyene, used only for treating life-threatening infections?
■ Why is flucytosine generally used only in combination with other drugs?
■ If griseofulvin were not concentrated in keratin-containing structures, would it still be toxic to fungi that invade these structures? Why or why not?
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