Mutations and transfer of genetic information have enabled microorganisms to develop resistance to each new antimicrobial drug that has been developed. Drug resistance affects the cost, complications, and outcomes of medical treatment. Slowing the emergence and spread of bacteria involves the cooperation of health care personnel, educators, and the general public.
■ Explain how using a combination of two antimicrobial drugs helps prevent the development of spontaneously resistant mutants.
■ Explain the significance of a member of the normal flora that harbors an R plasmid.
■ A student argued that "spontaneous mutation" meant that a drug could cause mutations. Is the student correct? Why or why not?
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