Microcheck 214

The minimum inhibitory concentration and minimum bactericidal concentration are quantitative measures of a bacterial strain's susceptibility to an antimicrobial drug. Disc diffusion tests can determine whether an organism is sufficiently susceptible to a specific drug for it to successfully be used in treatment. Commercial tests for determining antimicrobial sensitivity are less labor-intensive and often more rapid.

■ Explain the difference between the MIC and the MBC.

Figure 21.12 The E Test The strip is impregnated with a gradient of concentrations of a given antimicrobial drug.The MIC is determined by reading the number on the strip at the point at which growth intersects the strip.

Figure 21.12 The E Test The strip is impregnated with a gradient of concentrations of a given antimicrobial drug.The MIC is determined by reading the number on the strip at the point at which growth intersects the strip.

21.5 Resistance to Antimicrobial Drugs 521

Antimicrobial drug is added; sensitive organisms are killed or inhibited

Antimicrobial drug is added; sensitive organisms are killed or inhibited

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