Immunodeficiencies may be primary, either genetic or developmental defects in any components of the immune response, or they may be secondary, acquired as a result of infection or environmental influences.
■ What is the defect in severe combined immunodeficiency? What could cause it?
■ Multiple myeloma is a plasma cell tumor in which a clone of malignant plasma cells produces large amounts of immunoglobulin. With all this excess immunoglobulin, how can a person with multiple myeloma be immunodeficient?
■ Why is infection with opportunistic agents a particular problem in individuals with AIDS?
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