Type II cytotoxic hypersensitivity reactions are mediated by antibodies, either by complement lysis of cells or by antibody-dependent cellular cytotoxicity. Blood transfusion reactions and hemolytic disease of the newborn are examples.
■ Describe the mechanism of cell damage in a blood transfusion where ABO antigens are mismatched.
■ Why do Rh-negative but not Rh-positive mothers sometimes have babies with hemolytic disease of the newborn?
■ Why is the finding surprising that people lacking the A or B antigen are found to have antibodies to the corresponding antigen (anti-A or anti-B)?
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