Microcheck 181

Hypersensitivity reactions are immunological reactions that cause tissue damage. Type I hypersensitivity reactions mediated by cell-bound IgE antibodies occur immediately after exposure to antigen. The reactions are caused by the release of mediators from mast cell granules. Localized anaphylactic reactions include hives, hay fever, and asthma; generalized reactions lead to anaphylactic shock. Immunotherapy is directed toward

Wheal

Flare

IgG antibody

-pr Granules containing mediators

cell _Mast cell surface

IgG antibody

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