Mechanisms used to generate the diversity of antigen specificity in lymphocytes include rearrangement of gene segments, imprecise joining of those segments, and combinatorial associations of heavy chains and light chains. Negative selection eliminates B cells and T cells that recognize normal "self" molecules. Positive selection permits only those T cells that show moderate recognition of the MHC molecules to develop further.
■ What three gene segments encode an antibody molecule?
■ What are autoantibodies?
■ How could imprecise joining be considered a type of frameshift mutation?
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