Mechanisms used to generate the diversity of antigen specificity in lymphocytes include rearrangement of gene segments, imprecise joining of those segments, and combinatorial associations of heavy chains and light chains. Negative selection eliminates B cells and T cells that recognize normal "self" molecules. Positive selection permits only those T cells that show moderate recognition of the MHC molecules to develop further.
■ What three gene segments encode an antibody molecule?
■ What are autoantibodies?
■ How could imprecise joining be considered a type of frameshift mutation?
Was this article helpful?
This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.