Microcheck 159

Fever results when macrophages release pro-inflammatory cytokines; this occurs when the toll-like receptors on the macrophages are engaged by microbial products.

■ What is an endogenous pyrogen? What is an exogenous pyrogen?

■ How does fever inhibit the growth of pathogens?

■ Syphilis was once treated by intentionally infecting the patient with the parasite that causes malaria, a disease characterized by repeated bouts of fever, shaking, and chills. Why would this treatment cure syphilis?

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