Info

Type

Characteristics

Non-competitive inhibition (by regulatory molecules)

Inhibitor temporarily changes the enzyme, altering the enzyme's relative affinity for the substrate. This mechanism provides cells with a mechanism to control the activity of allosteric enzymes.

Non-competitive inhibition (by enzyme poisons)

Inhibitor permanently changes the enzyme, rendering the enzyme non-functional. Enzyme poisons such as mercury are used in certain antimicrobial compounds.

Competitive inhibition

Inhibitor binds to the active site of the enzyme, obstructing the access of the substrate. Competitive inhibitors such as sulfa drugs are used as antibacterial medications.

Nester-Anderson-Roberts: I. Life and Death of 6. Metabolism: Fueling Cell © The McGraw-Hill

Microbiology, A Human Microorganisms Growth Companies, 2003

Perspective, Fourth Edition

Chapter 6 Metabolism: Fueling Cell Growth

^PABA (substrate)

Sulfa (inhibitor)

/ Sulfa molecules Sulfa more likely to

(inhibitor) bind to enzyme

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