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The entering DNA is methylated by a modification enzyme and becomes resistant to degradation by the restriction endonuclease.

Entering DNA -CH3

Methylated DNA

Entering DNA -CH3

Bacterial chromosome

Methylated DNA

Bacterial chromosome

The restriction endonuclease cleaves the foreign DNA before it has a chance to be methylated.

Figure 8.26 Restriction and Modification of Entering DNA (a)The entering DNA becomes methylated, thereby becoming resistant to degradation by the restriction enzyme. (b)The entering DNA is degraded before it can be methylated.

Figure 8.26 Restriction and Modification of Entering DNA (a)The entering DNA becomes methylated, thereby becoming resistant to degradation by the restriction enzyme. (b)The entering DNA is degraded before it can be methylated.

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