Fluoroquinolones Ciprofloxacin, ofloxacin

Bactericidal against a wide variety of Gram-positive and Gram-negative bacteria; inhibits topoisomerases. Resistance is most often due to structural alterations in the topoisomerase target.

Rifamycins Rifampin

Bactericidal against Gram-positive and some Gram-negative bacteria. Binds RNA polymerase, blocking the initiation of RNA synthesis. Primarily used to treat infections caused by Mycobacterium tuberculosis and as prophylaxis for patients who have been exposed to Neisseria meningitidis.

Folate Biosynthesis

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