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The repressor is synthesized as a form that alone cannot bind to the operator. When a molecule, termed a corepressor binds to it, however, its shape is altered so that it can bind to the operator, blocking transcription initiation.

The repressor is synthesized as a form that effectively binds to the operator, blocking transcription initiation. The binding to it of a molecule that functions as an inducer, alters the shape of the repressor so that it no longer binds to the operator. Consequently, the gene can be transcribed.

Mechanism 1

Repressor

Promoter (with RNA polymerase)

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