Info

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Causative agent

Influenza virus, an orthomyxovirus

new virus.

@ Newly formed virions bud from infected cells, they are released by viral neuraminidase and infect ciliated epithelium, mucus-secreting, and alveolar cells.

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Pathogenesis

Infection of respiratory epithelium; cells destroyed and virus released to infect other cells. Secondary bacterial infection results from damaged mucociliary escalator

@ Infected cells ultimately die and slough off; recovery of the mucociliary escalator may take weeks.

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