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Sulfonamides

Bacteriostatic against a variety of Gram-positive and Gram-negative organisms. Structurally similar to para-aminobenzoic acid (PABA) and therefore inhibits the enzyme for which PABA is a substrate. Resistance is most commonly due to a plasmid-encoded alternative enzyme.

Trimethoprim

Often used in combination with a sulfa drug for a synergistic effect; inhibits the enzyme that catalyzes a step following the one inhibited by the sulfonamides. Resistance is commonly due to a plasmid-encoded alternative enzyme; the genes that encode resistance to sulfa drugs are often carried on the same plasmid.

Cell Membrane Integrity

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