Immunoglobulin M IgM

IgM accounts for 5% to 13% of the circulating antibodies and is the first class produced during the primary response to an anti gen. It is the only class produced in response to T-independent antigens, a group of antigens that will be discussed later.

IgM found circulating in the blood is a pentamer. Its large size prevents it from crossing from the bloodstream into tissues, so its role is primarily to control bloodstream infections. The five monomeric subunits give IgM a total of 10 antigen-binding sites, making it very effective in agglutination and precipitation. It is the most efficient class in initiating the classical pathway of the complement cascade.

As a fetus is normally sterile until the birth membrane is ruptured, IgM generally begins being made about the time of birth. However, a fetus that is infected in utero is capable of making IgM antibodies.

Bacterial Vaginosis Facts

Bacterial Vaginosis Facts

This fact sheet is designed to provide you with information on Bacterial Vaginosis. Bacterial vaginosis is an abnormal vaginal condition that is characterized by vaginal discharge and results from an overgrowth of atypical bacteria in the vagina.

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