Il1

Macrophages, epithelial cells

Proliferation of lymphocytes; macrophage production of cytokines, induce adhesion molecules for PMNs on blood vessel cells; induce fever

IL-2 (T-cell growth factor)

T lymphocytes

Changes in growth of lymphocytes; activation of natural killer cells; promote adaptive cell-mediated immune responses

IL—3

T lymphocytes, mast cells

Changes in growth of precursors of blood cells and also of mast cells

IL-4, IL—5, IL—10, IL—14

T lymphocytes, mast cells, other cells

Promote antibody responses

IL—6

T lymphocytes, macrophages

T- and B-cell growth; production of acute-phase proteins; fever

Tumor Necrosis Factors (TNFs)

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