Macrophages, epithelial cells
Proliferation of lymphocytes; macrophage production of cytokines, induce adhesion molecules for PMNs on blood vessel cells; induce fever
IL-2 (T-cell growth factor)
Changes in growth of lymphocytes; activation of natural killer cells; promote adaptive cell-mediated immune responses
T lymphocytes, mast cells
Changes in growth of precursors of blood cells and also of mast cells
IL-4, IL—5, IL—10, IL—14
T lymphocytes, mast cells, other cells
Promote antibody responses
T lymphocytes, macrophages
T- and B-cell growth; production of acute-phase proteins; fever
Tumor Necrosis Factors (TNFs)
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