Bvf

Thymine

OH H Thymidine hXP-H H

Azidothymidine (AZT)

Figure 8.4 Common Base Analogs and the Normal Bases They Replace in DNA The important differences between the normal bases and the analogs are in boxes.The numbers refer to the carbon atoms in the ring, which are not shown. Thymidine consists of thymine and deoxyribose.

Sugar-phosphate backbone

Covalent bonds

Thymine

Sugar-phosphate backbone

Covalent bonds

Thymine

Thymine dimer

Thymine

Thymine dimer

Figure 8.5 Thymine Dimer Formation Covalent bonds form between adjacent thymine molecules on the same strand of DNA when DNA is exposed to UV light.This distorts the shape of the DNA and prevents replication past the dimer.

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