The target of one antifungal drug, griseofulvin, is cell division.
The exact mechanism of griseofulvin is unknown, but it appears to interfere with the action oftubulin, a necessary factor in nuclear division. Because tubulin is a part of all eukaryotic cells, the selective toxicity of this drug may be due to its greater uptake by fungal cells. When the drug is taken orally for months, it is absorbed and eventually concentrated in the dead keratinized layers of the skin. The fungi that then invade keratin containing structures such as skin and nails take up the drug, which prevents their multiplication. It is only active against fungi that invade keratinized cells and is used to treat skin and nail infections. ■ tubulin, p. 73 ■ keratin, p. 534
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