Postcpb Coagulopathy

Postoperative coagulopathy results from an activation of fibrinolysis and platelet dysfunction. Fibrinolysis is due to thrombin generation, fibrin production and activation of factor XII. Platelet dysfunction is due to fibrinolysis and plasmin formation with redistribution of platelet receptors.

Although there is no consensus as to the nature of damage inflicted on platelets by CPB the end point remains the same: platelet damage causes excessive blood loss after surgery performed under CPB.

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