Vascular rejection

A devastating, but fortunately rare, early complication of heart transplantation is vascular rejection, also called antibody-mediated or humoral rejection. Biopsy findings include evidence of endothelial cell proliferation and swelling by light microscopy and vascular deposition of immunoglobulin by immunofluorescence. Vascular rejection usually presents intraoperatively or in the first few days postoperatively. Clinically, vascular rejection manifests first with right ventricular failure followed quickly by left ventricular failure. Therapy for vascular rejection includes aggressive use of inotropes, vasopressors, and in some cases mechanical ventricular support or retransplantation. Medical treatment of vascular rejection may include cyclophosphamide and plasma exchange. Despite aggressive measures, vascular rejection is associated with a much higher mortality than acute cellular rejection.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

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