Tubuloglomerular feedback

Tubuloglomerular feedback or secondary intrarenal vasoconstriction is a regulatory mechanism which lowers glomerular filtration rate in response to increased solute delivery at the macula densa and may contribute to the decline in glomerular filtration rate in ARF. Renal ischemia induces tubular epithelial damage, impairing tubular reabsorptive properties and urinary concentration. Activation of tubuloglomerular feedback serves to conserve volume loss, precluding massive diuresis despite defective reabsorption, and to reduce the workload to the distal tubule as part of a co-ordinated system to preserve medullary oxygenation ( Fig 1).

Was this article helpful?

0 0
Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

Get My Free Ebook

Post a comment