Tubuloglomerular feedback

Tubuloglomerular feedback or secondary intrarenal vasoconstriction is a regulatory mechanism which lowers glomerular filtration rate in response to increased solute delivery at the macula densa and may contribute to the decline in glomerular filtration rate in ARF. Renal ischemia induces tubular epithelial damage, impairing tubular reabsorptive properties and urinary concentration. Activation of tubuloglomerular feedback serves to conserve volume loss, precluding massive diuresis despite defective reabsorption, and to reduce the workload to the distal tubule as part of a co-ordinated system to preserve medullary oxygenation ( Fig 1).

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