Trimethoprim and trimethoprimsulfamethoxazole cotrimoxazole

Trimethoprim and sulfamethoxazole act at different parts of the same pathway of synthesis of bacterial folate. Their long half-lives allow both to be given at 12-h intervals. Trimethoprim is active against most staphylococci, streptococci (not enterococci), Enterobacteriaceae, and Hemophilus species, but not Ps. aeruginosa or anaerobes. Trimethoprim can be used for urinary tract infection but in hospital-acquired infections susceptibility needs first to be demonstrated. Sulfamethoxazole adds little to trimethoprim for most infections, but trimethoprim-sulfamethoxazole is commonly used to treat Pneumocystis pneumonia in AIDS. Adverse effects are common at the high dose used (120 mg/kg/day intravenously in four divided doses) and are due mostly to the sulfonamide. Rash, nausea, vomiting, and diarrhea are common, and occasionally Stevens-Johnson syndrome occurs. Administration in pregnancy is contraindicated.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

Get My Free Ebook

Post a comment