Trimethoprim and trimethoprimsulfamethoxazole cotrimoxazole

Trimethoprim and sulfamethoxazole act at different parts of the same pathway of synthesis of bacterial folate. Their long half-lives allow both to be given at 12-h intervals. Trimethoprim is active against most staphylococci, streptococci (not enterococci), Enterobacteriaceae, and Hemophilus species, but not Ps. aeruginosa or anaerobes. Trimethoprim can be used for urinary tract infection but in hospital-acquired infections susceptibility needs first to be demonstrated. Sulfamethoxazole adds little to trimethoprim for most infections, but trimethoprim-sulfamethoxazole is commonly used to treat Pneumocystis pneumonia in AIDS. Adverse effects are common at the high dose used (120 mg/kg/day intravenously in four divided doses) and are due mostly to the sulfonamide. Rash, nausea, vomiting, and diarrhea are common, and occasionally Stevens-Johnson syndrome occurs. Administration in pregnancy is contraindicated.

Healthy Fat Loss For A Longer Life

Healthy Fat Loss For A Longer Life

What will this book do for me? A growing number of books for laymen on the subject of health have appeared in the past decade. Never before has there been such widespread popular interest in medical science. Learn more within this guide today and download your copy now.

Get My Free Ebook


Post a comment