The normal hemostatic pathway

When a blood vessel is injured, an immediate vasoconstriction of the injured vessel and adjacent small arteries and arterioles is responsible for an initial slowing of blood flow to the areas of injury. A series of interactions then results in the formation of a platelet plug which is rapidly stabilized by cross-linking fibrin strands. These procoagulant processes are limited and localized by a number of control mechanisms. It is convenient to divide them into five functional components: platelet function, coagulation cascade, natural anticoagulants, fibrinolysis, and endothelium.

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