Adverse effects are uncommon and include headache, fever, chills, gastrointestinal symptoms, and occasionally hypersensitivity reactions and anaphylaxis. Anti-T-lymphocyte antibodies (e.g. anti-CD3) may be associated with T-cell activation and cytokine release with symptoms ranging from an influenza-like illness to shock and cardiac arrest. Murine, chimeric, and heteromyeloma antibodies can also stimulate the development of anti-mouse antibodies (10 to 30 days after exposure) which, although not generally a life-threatening problem, reduce clinical efficacy.
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