Sideeffects

As mannitol distributes relatively rapidly into the extracellular space, the administration of hypertonic solution will inevitably be accompanied by a mobilization of fluid from the intracellular space with resulting hyponatremia, hyperkalemia, and metabolic acidosis. These adverse events mainly occur in patients who are unable to increase their urine output. Pulmonary edema may follow because the heart is unable to cope with the increased intravascular volume. Finally, toxic vacuolization of epithelial cells of the late tubule and collecting system has been described following mannitol.

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