Aprotinin has few side-effects, but allergic and pseudoallergic reactions have been reported. It should be noted that aprotinin prolongs the activated clotting time which cannot, therefore, be used to assess heparin therapy. Chapter References

Brunet, F., et al. (1992). Effects of aprotinin on hemorrhagic complications in ARDS patients during prolonged extracorporeal CO 2 removal. Intensive Care Medicine, 18, 364-7. Fritz, H. and Wunderer, G. (1983). Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs. Arzneimittelforschung, 33, 479-94. Royston, D. (1990). The serine antiprotease aprotinin (Trasylol): a novel approach to reducing postoperative bleeding. Blood Coagulation and Fibrinolysis, 1, 55-69.

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