Sepsis

Pyrexia increases the cerebral metabolic requirement for oxygen and may also exacerbate raised ICP. High core temperatures in seriously injured trauma patients have been shown to be associated with a poor prognosis. A high temperature should be assumed to be associated with infection, and appropriate endotracheal, urine, and blood cultures should be sent. In patients with ventricular access for ICP monitoring, the cerebrospinal fluid should be sampled daily. Core temperatures above 38 °C should be actively treated using combinations of antipyretics, such as acetaminophen (paracetamol), and physical methods such as tepid sponging, fanning, and cooling blankets.

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