Secondary causes of chronic pulmonary hypertension

Chronic pulmonary hypertension develops when the underlying disease is not diagnosed because the pathophysiological changes are mild and do not result in clinical symptomatology (e.g. congenital heart diseases, thromboembolic disease), or when the primary disease becomes chronic despite adequate therapy (e.g. inflammatory or infectious diseases). The pathophysiological alterations of the pulmonary circulation are progressive and are mainly determined by the time course of vascular remodeling. All entities except primary pulmonary hypertension result in pulmonary hypertension secondary to an underlying disease ( Table.3).

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