Respiratory center dysfunction

Decreased activity of the respiratory centers may be due to the following:

1. structural damage (e.g. cerebral infarction, neoplasm, infection);

2. central nervous system depressants (e.g. narcotics or barbiturates);

3. metabolic abnormalities (e.g. metabolic alkalosis, hypothyroidism, starvation);

4. loss of sensitivity to changes in PaCO2 (e.g. primary alveolar hypoventilation (Ondine's curse));

5. periodic cessation of impulse formation during sleep (central sleep apnea).

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