Renal metabolism

In addition to its higher blood flow per weight than other vital organs, the kidney exhibits a higher rate of oxygen consumption than all other organs except the heart. The kidney normally plays a major role in the catabolism of low-molecular-weight proteins (insulin, glucagon, PTH). Reductions in glomerular filtration rate reduce protein filtration, hence decreasing renal protein catabolism and elevating plasma protein levels. Renal degradation of larger proteins (albumin) is normally minimal, although increased protein excretion (nephrotic syndrome) significantly enhances intrarenal protein catabolism.

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