Q mg Vd lkg x C mgl x W kg

where Q is the amount of drug, Vd is the apparent volume of distribution of the drug, C is the concentration of the drug, and W is the body weight. Thus the amount of drug eliminated can be calculated by subtracting the concentration at time tn (blood concentration at a given time n after presentation) from the concentration at time to (initial blood concentration) and multiplying by the body weight and apparent volume of distribution. The amount of drug excreted in the urine is then subtracted from this total. In the absence of significant lung elimination, the remaining drug elimination is accounted for by hepatic clearance (metabolism and biliary excretion).

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