Cytokine activity in the hypothalamus is thought to be mediated by increased prostaglandin production, primarily of the prostaglandin E 2 (PGE2) class (Fig.,.2). Thus microinjections of PGE2 in the organum vasculosum of the lamina terminalis produce fever, and cyclo-oxygenase inhibitors such as aspirin and indomethacin, which block prostaglandin synthesis, inhibit fever following inflammatory stimuli. Prostaglandin F 2 may also have a role. Final cellular pathways are thought to involve cyclic AMP.
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