Cytokine activity in the hypothalamus is thought to be mediated by increased prostaglandin production, primarily of the prostaglandin E 2 (PGE2) class (Fig.,.2). Thus microinjections of PGE2 in the organum vasculosum of the lamina terminalis produce fever, and cyclo-oxygenase inhibitors such as aspirin and indomethacin, which block prostaglandin synthesis, inhibit fever following inflammatory stimuli. Prostaglandin F 2 may also have a role. Final cellular pathways are thought to involve cyclic AMP.

Was this article helpful?

0 0
Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

Get My Free Ebook

Post a comment