Prolactin in critical illness

Prolactin, which is secreted by the anterior pituitary to promote lactation, also has an immunoregulatory role. Both T and B lymphocytes have prolactin receptors. The immunosuppressive effect of cyclosporin is probably due, in part, to the fact that it competes for the prolactin binding site on T cells.

Prolactin concentrations increase in acute stress but are normal or reduced in long-term stress such as that associated with critical illness. This may be explained by the prolonged increase in glucocorticoid production which is thought to inhibit prolactin release. This prolactin deficiency state would impair immune function, particularly cell-mediated immunity, although the physiological significance is unclear.

Healthy Fat Loss For A Longer Life

Healthy Fat Loss For A Longer Life

What will this book do for me? A growing number of books for laymen on the subject of health have appeared in the past decade. Never before has there been such widespread popular interest in medical science. Learn more within this guide today and download your copy now.

Get My Free Ebook


Post a comment