Prokinetics

Metoclopramide and domperidone are dopamine-D2 receptor antagonists with predominant action on the chemoreceptor trigger zone. Both are well absorbed from the gut. For vomiting in the ICU, 10 mg metoclopramide is usually given intravenously. A daily dose of 3 to 10 mg/kg has been used for vomiting during cancer chemotherapy. The most common side-effects of metoclopramide are extrapyramidal reactions. Renal failure prolongs the excretion half-life from approximately 4 to 14 h. Domperidone penetrates the blood-brain barrier poorly, and so central side-effects are rare; however, no intravenous form is available as this causes cardiac arrest.

Kicking Fear And Anxiety To The Curb

Kicking Fear And Anxiety To The Curb

Kicking Fear And Anxiety To The Curb Can Have Amazing Benefits For Your Life And Success. Learn About Calming Down And Gain Power By Learning Ways To Become Peaceful And Create Amazing Results.

Get My Free Ebook


Post a comment