Metoclopramide and domperidone are dopamine-D2 receptor antagonists with predominant action on the chemoreceptor trigger zone. Both are well absorbed from the gut. For vomiting in the ICU, 10 mg metoclopramide is usually given intravenously. A daily dose of 3 to 10 mg/kg has been used for vomiting during cancer chemotherapy. The most common side-effects of metoclopramide are extrapyramidal reactions. Renal failure prolongs the excretion half-life from approximately 4 to 14 h. Domperidone penetrates the blood-brain barrier poorly, and so central side-effects are rare; however, no intravenous form is available as this causes cardiac arrest.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

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