Preemptive analgesia

Pre-emptive analgesia refers to interventions aimed at preventing the development of central sensitization, resulting in reduced requirement for analgesia and a lower incidence of chronic pain syndromes. This is of clinical relevance, as approximately 70 per cent of patients attending our pain center have chronic pain arising from an acute noxious event. Acute and chronic pain models reveal a greater effect from local or systemic analgesia administered before rather than after a noxious stimulus, but the clinical evidence is not so clear cut. Methodological reasons may account for this.

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